Baclofen 10mg, known as Lioresal, is a GABAB receptor agonist that is used to alleviate the signs and symptoms of muscle spasticity from Multiple Sclerosis. It is thought to inhibit transmission of reflexes at the spinal cord level. Off-label uses of Baclofen include treatment of trigeminal neuralgia, tardive dyskinesia and intractable hiccups. Baclofen is available in tablets with the initial dose of 5 mg three times a day to a maximum of 80 mg per day for treatment of muscle spasticity. Hallucinations and seizures have occurred on abrupt withdrawal of Baclofen.
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Baclofen has been used to treat other stimulant addictions such as amphetamine and methamphetamine addiction as well as addiction to over-the-counter drugs that contain stimulants. It is often prescribed in drug rehab centers for dual diagnosis treatment for addiction. In a study conducted and presented at the Royal College of Psychiatrists' Faculty of Addictions Psychiatry Annual Meeting, researchers found benefits of using Baclofen for the treatment of alcohol dependence and cravings. Baclofen can be administered via two methods: the intrathecal route and the oral route. Baclofen intrathecal is injected into the fluid of the spinal cord, thus acting as a CNS depressant. Baclofen relaxes the muscles, relieving the sufferer of cramps and tightness. Baclofen intrathecal must be administered under the supervision of a physician.
Baclofen is a drug which can cause serious harm to the patient if administered incorrectly, especially with intrathecal administration. Baclofen should not be prescribed with other tricyclic antidepressants, as the combination can cause depressed brain function and muscle weakness. It must be used with caution and closely monitored when used on patients with diabetes. Side Effects of Baclofen Oral include: Confusion, Constipation, Frequent need to urinate, Headache, Nausea, Weakness, Palpitations. Side Effects of Baclofen Intrathecal may include: Dry mouth, Vision problems, False sense of well being, Unsteadiness, Fainting, Seizures.
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